#5045 CARDIORESPIRATORY FITNESS IN KIDNEY TRANSPLANT RECIPIENTS: A CASE-CONTROL STUDY AND INITIAL REVIEW OF THE EFFECTS OF A HOME-BASED EXERCISE PROGRAMME

Abstract Background and Aims Kidney transplant recipients (KTRs) have an increased burden of cardiovascular disease (CVD) due to clustering traditional non-traditional risk factors. Poor cardiorespiratory fitness (CRF) is linked higher levels morbidity mortality. Cardiorespiratory a significant predictor 7-year mortality, with each 1 ml/kg/min increase in VO2 associated 1% decrease mortality.[1] Although KTRs CRF than patients kidney failure, performance compared the general population has not been quantified. Neither link between physical function. We assessed differences healthy volunteers case-control study. then explored relationships function possible effects 12-week structured home-based exercise programme KTRs. Method Case-control: 20 (10 male; age 61.2 ±8.1 years; body mass 84.1 ±19.9 kg) 61.9 ±7.7 76.7 ±18.1 completed continuous ramp cardiopulmonary test (CPET) volitional exhaustion on cycle ergometer. CPET variables were groups using independent samples t-tests. Thirteen (6 47.8 ±15.9 eGFR 64.6 ±19.1 ml/min/1.73 m2), date, structured, combined aerobic resistance, as part pilot randomised controlled trial.[2] Bivariate correlations used explore association measures (sit-to-stand 60 [STS60], timed up go [TUAG], gait speed [GS] handgrip strength [HGS]). Paired t-tests compare pre- post-intervention variables. Results (VO2 peak) was lower (18.4±5.2 mL/kg/min) (24.3 ±5.9 mL/kg/min), difference 5.9 mL/kg/min (95% CI, 2.4-9.5), t(38) = 3.35, p <.001. Peak heart rate achieved (154 v 136 bpm; .009). Maximum power but did reach significance (147 116 W; .052). There positive correlation STS60 peak (r .652, .016) GS .583, .037). negative TUAG .-.664, .013) no HGS peak. after (19.4±4.5 20.4±5.0 mL/kg/min, .018). change (118 121 .423). only improve (24 27; .010). Conclusion significantly impaired control subjects. In KTRs, correlated field tests assessing Initial findings suggest that may following exercise, these data need confirming larger studies will be final analysis this trial.